Cancer Science· 2026Q1
EPHX2 Loss Promotes CRC Migration via EET ‐Dependent Chemokine Elevation and Mitochondrial Defect
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- Q1SCImago
- 2026year
Short summary
Loss of Epoxide hydrolase 2 (EPHX2) in colorectal cancer (CRC) promotes cell migration by increasing chemokines (CXCL) and impairing mitochondrial biogenesis through EET accumulation.
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Key points
- EPHX2 is downregulated in CRC tissues and correlates with poor prognosis.
- Loss of EPHX2 increases CXCL levels and suppresses mitochondrial biogenesis.
- EET accumulation is the mechanism linking EPHX2 loss to mitochondrial defects.
- EPHX2 loss promotes CRC cell migration through ROS and CXCL signaling.
AI-generated from the title and abstract; the full text is not read.
Abstract
Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and carcinogenesis. However, the role and mechanism of EPHX2 in colorectal cancer (CRC) migration remain unclear. In this study, we employed an integrated approach of bioinformatics and functional experiments to examine EPHX2 expression, its clinical implications, and its mechanistic role in CRC migration. Our results showed that EPHX2 was significantly downregulated in CRC tissues, and its low expression correlated with poor prognosis. Overexpression of EPHX2 led to accumulation of HDHA, HEPE, and HETE in CRC cells, whereas loss of EPHX2 increased CXCL levels and suppressed mitochondrial biogenesis via EET accumulation. Furthermore, loss of EPHX2 promoted cell migration through ROS and CXCL signaling. Collectively, loss of EPHX2 accelerates cell migration via EET accumulation-dependent chemokine elevation and mitochondrial biogenesis impairment in CRC. These findings reveal a novel metabolic-mitochondrial axis in CRC progression and highlight EPHX2 as a potential therapeutic target.
The authors' abstract, as published at the source. Cancer Science, 2026 · DOI ↗
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Field: Biochemistry (Biochemistry, Genetics and Molecular Biology)
BiochemistryBiochemistry, Genetics and Molecular Biology