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Acta Neuropathologica Communications· 2026Q1

A standardized framework resolves ambiguity in motor neuron loss across neurodegenerative diseases

Leonie Sowoidnich, Aaron L Norman, Florian Gerstner, Josiane Kelly Siemund et al.

Short summary

A new framework using whole-segment spinal cord analysis, tissue clearing, and deep learning-based segmentation resolves ambiguity in motor neuron (MN) loss quantification, reducing variability from 60% to enable accurate degeneration pattern analysis in diseases like ALS and SMA.

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Field: Genetics

GeneticsMedicine