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Nature Plants· 2026Q1

Mapping genetic modifiers of epimutation rates identifies VIM2/4 as dosage-sensitive negative regulators of CG methylation maintenance

Zhilin Zhang, Wilma Wanney, Yangyang Xu, Johan Zicola et al.

Short summary

A deletion between VIM2 and VIM4 in Arabidopsis thaliana increases VIM2/4 expression, leading to a 10-fold higher epimutation rate and a shift towards lower CG methylation levels.

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Plant ScienceAgricultural and Biological Sciences