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JAMA Network Open· 2026Q1

Lifelong Genetic Inhibition of PCSK9 and Hepatic Safety

Alessia Di Costanzo, Ilaria Pirona, Laura D’Erasmo, Silvia Buonaiuto et al.

Short summary

Rare loss-of-function variants in PCSK9 are associated with a reduced risk of liver-related outcomes, suggesting lifelong PCSK9 inhibition is safe for the liver.

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Field: Surgery

SurgeryMedicine