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BMC Oral Health· 2026Q1

Effect of simvastatin versus calcium hydroxide intracanal medications on postoperative pain and cytokine modulation in symptomatic apical periodontitis: a randomized controlled trial

Mohammed Essam Othman Alghidany, Dina Morsy, Olfat Shaker, R. M. El Boghdadi

Short summary

Simvastatin gel significantly reduced postoperative pain at 6 hours (p=0.037) and decreased IL-6 (p=0.017) and IL-8 (p=0.002) levels compared to calcium hydroxide in patients with symptomatic apical periodontitis.

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Field: Oral Surgery

Oral SurgeryDentistry