Kırsal Bangladeş'te Kadınlar ve Çocuklarda Kronik Mikotoksin Maruziyeti ve İlişkili Sağlık Risklerinin Karakterizasyonu

Özet (abstract)

Abstract Dietary exposure to mycotoxins—including aflatoxins (AFs), ochratoxin A (OTA), and citrinin (CIT)—represents an important health risk, particularly in low-resource settings with widespread food contamination. This study investigates mycotoxin exposure among 712 participants (428 women and 284 children) of a cluster-randomized trial in rural Bangladesh, using blood samples collected in 2019. A total of 712 plasma and 578 serum samples were analyzed by ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Serum aflatoxin B1 (AFB 1 )-lysine adducts were quantified following enzymatic digestion and solid-phase extraction. To evaluate potential health risks, we estimated probable daily intake (PDI) from blood concentrations of frequently detected mycotoxins. All plasma samples contained at least two mycotoxins, and 84% of participants were co-exposed to at least three mycotoxins. Biomarkers for the main blood-relevant mycotoxins were frequently detected, with OTA and its isomer, 2′R-ochratoxin A (2’R-OTA), found in nearly every sample, CIT in 91%, and Enniatin B (EnB) in 92%, while AFB1-lysine—a biomarker of chronic exposure to the potent carcinogen AFB1—was detected in nearly one-quarter of women and 4% of children with serum samples. Beauvericin was detected in 6% of samples. The PDI of OTA exceeded health-based guidance values for up to 80% of women and 99% of children, while the PDI of CIT was of concern for 12% of women and 27% of children. These findings demonstrate widespread co-exposure to multiple mycotoxins, with OTA, CIT, and AFB 1 posing notable risks, underscoring the urgent need for targeted interventions to protect vulnerable populations.

Yazarların özeti; kaynağından alınmıştır. Environmental Health, 2026 · DOI ↗