Science· 2026Q1

Early-life colonization with Clostridioides difficile remodels the developing gut

Alexa Semon, Haider S. Manzer, Orlaith Keenan, Tao-You Zhou et al.

2citations
Q1SCImago
2026year

Short summary

Early-life colonization with *Clostridioides difficile* in mice permanently reshapes the developing gut epithelium, enriching injury-associated stem cells and skewing differentiation towards secretory lineages, even after transient colonization.

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Field: Infectious Diseases

Infectious DiseasesMedicine