Journal of Clinical Investigation· 2026Q1
Imaging B cell maturation antigen in multiple myeloma
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- Q1SCImago
- 2026year
Short summary
A novel nanobody tracer, [68Ga]Ga-PFBC01, targeting B cell maturation antigen (BCMA) shows high sensitivity for visualizing multiple myeloma.
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Key points
- A nanobody tracer, [68Ga]Ga-PFBC01, targets B cell maturation antigen (BCMA) for PET imaging in multiple myeloma.
- The tracer demonstrated high sensitivity in a prospective phase I study.
- Imaging results correlate with tissue and circulating disease measures.
- The approach shifts myeloma imaging from metabolic assessment to target biology.
AI-generated from the title and abstract; the full text is not read.
Abstract
Multiple myeloma is a systemic and spatially heterogeneous cancer of plasma cells. Available methods for diagnosing and monitoring disease do not fully capture its heterogeneity. For instance, bone marrow sampling is anatomically limited and [ 18 F]FDG PET/CT reflects glucose metabolism rather than a specific target. In this issue of JCI , Gu et al. reported a prospective phase I study of [ 68 Ga]Ga-PFBC01, a nanobody tracer targeting B cell maturation antigen (BCMA). The study presents a coherent translational pathway for [ 68 Ga]Ga-PFBC01 PET and demonstrates high sensitivity, associations with tissue and circulating disease measures, and clinical management impact. By shifting myeloma imaging from metabolic assessment toward target biology, [ 68 Ga]Ga-PFBC01 PET may visualize whole-body disease distribution and actionable target expression, while blood-pool activity may reflect systemic antigen biology (Figure 1).
The authors' abstract, as published at the source. Journal of Clinical Investigation, 2026 · DOI ↗
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Field: Hematology
HematologyMedicine