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Neuropsychopharmacology· 2026Q1

Deletion of N-ethylmaleimide-sensitive factor in dopamine D2 receptor-expressing cells impairs striatal development and dopaminergic function and induces ADHD-like behaviors in mice

Min-Jue Xie, Koshi Murata, Hiroshi Kuniishi, Yugo Fukazawa et al.

Short summary

Deleting N-ethylmaleimide-sensitive factor (NSF) in dopamine D2 receptor (D2R)-expressing cells in mice reduced D2R cell density, striatal dopamine levels, and induced ADHD-like behaviors (hyperactivity, impulsivity).

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Field: Psychiatry and Mental health

Psychiatry and Mental healthMedicine