First characterization of Staphylococcus felis in diabetic foot osteomyelitis: from intracellular persistence to phage treatment

Short summary

This study characterizes Staphylococcus felis, a cat commensal, as a pathogen in diabetic foot osteomyelitis, demonstrating its ability to form biofilms, persist intracellularly in osteoblasts, and cause lethal infection in zebrafish. Sequential isolates from the same patient showed microevolutionary changes in virulence and phage susceptibility, with the phage SAVM02 effectively inhibiting growth in vitro and conferring protection in vivo.

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