Molecules· 2026Q1
Head-to-Tail Cyclization and D-Amino Acid Substitution Redesign the Biological Activities of a Naturally Occurring Amphibian Peptide
- 0citations
- Q1SCImago
- 2026year
Short summary
Head-to-tail cyclization of amphibian peptide Hp-1891 enhanced inhibition of AChE, BChE, and SARS-CoV-2 Mpro by up to 3-fold, while D-amino acid substitution increased antioxidant activity and reduced hemolysis.
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