Journal of the American Chemical Society· 2026Q1
Metal-Dependent Coordination Geometry Controls Autolytic Amide Bond Cleavage to Enable Prodrug Activation
- 0citations
- Q1SCImago
- 2026year
Short summary
A novel prodrug activation strategy, termed TMAC, uses trivalent metal ions (Ga3+, Fe3+, In3+, Co3+) to trigger amide bond cleavage, enabling tunable release of cytotoxic payloads like MMAE.
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