Molecules· 2026Q1

Carboxyl Amidation of Chlorogenic Acid Improves Anti-Inflammatory Activity and Biosafety via Potent AKR1B1 Inhibition in LPS-Induced Macrophages

Faliu Yang, Chunmei Guang, Huan Chen, Hongwei Hou

0citations
Q1SCImago
2026year

Short summary

A novel chlorogenic acid amide derivative (CGAA) shows improved anti-inflammatory activity and cellular safety compared to parent compounds by potently inhibiting AKR1B1 (IC50 = 7.85 μM).

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Cell BiologyBiochemistry, Genetics and Molecular Biology