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Angewandte Chemie International Edition· 2014Q1

The Hydrophobic Effect Revisited—Studies with Supramolecular Complexes Imply High‐Energy Water as a Noncovalent Driving Force

Frank Biedermann, Werner M. Nau, Hans‐Jörg Schneider

Short summary

Supramolecular complex studies reveal that the hydrophobic effect is driven by the enthalpic release of high-energy water from cavities, rather than entropic arguments or solvent-occupied surfaces.

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Field: Physical and Theoretical Chemistry

Physical and Theoretical ChemistryChemistry