Nucleic Acids Research· 2020Q1
The InterPro protein families and domains database: 20 years on
- 2,420citations
- Q1SCImago
- 2020year
Short summary
The InterPro database, a comprehensive resource for protein classification, has reached its 20th year of operation, marked by significant updates to its content and associated software.
AI-generated from the title and abstract; the full text is not read.
Key points
- InterPro provides an integrated classification of protein sequences, families, and domains.
- InterProScan is the software used to search sequences against InterPro's predictive models (signatures).
- The database has been updated to version 81.0, with new content and features.
- New developments include a redesigned website and a REST API for programmatic access.
- Performance improvements have been made to the InterProScan software.
AI-generated from the title and abstract; the full text is not read.
Abstract
The InterPro database (https://www.ebi.ac.uk/interpro/) provides an integrative classification of protein sequences into families, and identifies functionally important domains and conserved sites. InterProScan is the underlying software that allows protein and nucleic acid sequences to be searched against InterPro's signatures. Signatures are predictive models which describe protein families, domains or sites, and are provided by multiple databases. InterPro combines signatures representing equivalent families, domains or sites, and provides additional information such as descriptions, literature references and Gene Ontology (GO) terms, to produce a comprehensive resource for protein classification. Founded in 1999, InterPro has become one of the most widely used resources for protein family annotation. Here, we report the status of InterPro (version 81.0) in its 20th year of operation, and its associated software, including updates to database content, the release of a new website and REST API, and performance improvements in InterProScan.
The authors' abstract, as published at the source. Nucleic Acids Research, 2020 · DOI ↗
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Field: Spectroscopy
SpectroscopyChemistry