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Expert Opinion on Drug Discovery· 2015Q1· Review

The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities

Samuel Genheden, Ulf Ryde

Short summary

MM/PBSA and MM/GBSA methods are popular for estimating ligand-binding affinities, offering a balance between accuracy and computational cost compared to simpler or more complex methods.

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Field: Computational Theory and Mathematics

Computational Theory and MathematicsComputer Science