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Nature Neuroscience· 2026Q1

Intracranial recordings in humans reveal differential contributions of medial and lateral orbitofrontal cortex to approach–avoidance decision-making

Clara Kwon Starkweather, Ethan H. Willbrand, Kristin K. Sellers, Patrick W. Hullett et al.

Short summary

Intracranial recordings in humans show distinct medial and lateral orbitofrontal cortex (OFC) activity patterns preceding approach decisions, suggesting a new functional architecture within the OFC for handling approach-avoidance conflicts.

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Field: Cognitive Neuroscience

Cognitive NeuroscienceNeuroscience