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Metabolites· 2026Q2· Review

Coffee, the Gut Microbiome, and Host Metabolism: Gastrointestinal Fate, Microbial Transformation, Mechanistic Insights, and Prospects for Precision Nutrition

Lei Yang, Chaowei Wang, Liangyu Cui, Yongxiang Zhu et al.

Short summary

Coffee's metabolic benefits may stem from interactions between its constituents (caffeine, CGAs, etc.) and the gut microbiome, leading to altered short-chain fatty acids, phenolic acids, and bile acid metabolism, which in turn influence host energy, glucose, and lipid regulation.

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Field: Pharmacology

PharmacologyMedicine