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Journal of Chemical Information and Modeling· 2026Q1

Measuring AI Progress in Drug Discovery: A Reproducible Leaderboard for the Tox21 Challenge

Antonia Ebner, Christoph Bartmann, Sonja Topf, Günter Klambauer et al.

Short summary

A new reproducible leaderboard using the original Tox21 Challenge data set reveals that top-performing AI models for toxicity prediction have not significantly advanced since 2015-2017, questioning the extent of progress in the field.

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Field: Computational Theory and Mathematics

Computational Theory and MathematicsComputer Science