Total Syntheses and Structural Reassignment of Ugonin T and Neougonin B: Anti-inflammatory Flavonoids Related to Helminthostachys zeylanica

Short summary

Researchers successfully synthesized ugonin C, ugonin F, and compounds initially identified as ugonin T and neougonin B, ultimately reassigning the structures of ugonin T to compound 23a and neougonin B to compound 19 based on synthetic and NMR data. Compound 27a demonstrated potent anti-inflammatory activity by inhibiting NF-κB nitric oxide production in BV2 microglial cells.

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