Journal of Agricultural and Food Chemistry· 2026Q1
Novel Isoxazoline Amide Derivatives with Diaryl Sulfide Fragment as Potential Insecticides
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- Q1SCImago
- 2026year
Short summary
A new class of 41 isoxazoline amide derivatives, incorporating a diaryl sulfide fragment, demonstrated potent insecticidal activity against Plutella xylostella and Spodoptera litura, with FSC36 showing superior efficacy to fluxametamide and significantly lower toxicity to honey bees.
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Key points
- 41 new isoxazoline amide derivatives with a diaryl sulfide fragment were synthesized.
- Most compounds showed potent insecticidal activity against Plutella xylostella and Spodoptera litura.
- FSC36 exhibited superior insecticidal activity (LC50 0.84 mg/L vs. P. xylostella, 1.52 mg/L vs. S. litura) compared to fluxametamide (1.53 mg/L, 2.05 mg/L).
- FSC36 demonstrated significantly lower acute oral toxicity to honey bees (LD50 2.77 mg/L) than fluralaner (0.19 mg/L) and fluxametamide (0.92 mg/L).
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Isoxazoline insecticides exhibit broad-spectrum and highly effective insecticidal activity by acting on insect GABA receptors. Existing insecticides have high toxicity towards non-target organisms, such as bees, limiting their practical use. This study utilized an active group splicing approach to create 41 new isoxazoline compounds (FSC1–FSC41). Bioassays indicated that most compounds displayed potent insecticidal activity against Plutella xylostella and Spodoptera litura. Particularly, FSC36 exhibited the highest activity, with LC50 values of 0.84 mg/L and 1.52 mg/L against P. xylostella and S. litura, surpassing the commercial compound fluxametamide (1.53 mg/L and 2.05 mg/L). Acute oral toxicity tests on honey bees showed FSC36 to have an LD50 of 2.77 mg/L, lower than fluralaner (0.19 mg/L) and fluxametamide (0.92 mg/L), overcoming the “high efficacy–high toxicity” challenge. This research offers a foundation for developing novel isoxazoline insecticides that are highly effective and environmentally friendly.
The authors' abstract, as published at the source. Journal of Agricultural and Food Chemistry, 2026 · DOI ↗
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Field: Insect Science
Insect ScienceAgricultural and Biological Sciences