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Journal of Clinical Medicine· 2026Q2· Review

Oral Second-Generation H1-Antihistamine Regimens for Allergic Rhinitis: Systematic Review and Network Meta-Analysis of Effects and Estimability

José David Maya Viejo, Fernando Maria Navarro Ros, Eva Trillo‐Calvo, Luis Richard Rodríguez

Short summary

A systematic review and network meta-analysis found that evidence for oral second-generation H1-antihistamines in allergic rhinitis is sparse and predominantly placebo-anchored, failing to establish a reliable hierarchy or therapeutic equivalence among regimens.

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Field: Immunology and Allergy

Immunology and AllergyMedicine