Key papers in Immunology and Allergy
Pofolia’s corpus holds 57 papers from the Immunology and Allergy subfield (2012–2023). The list below starts with the most cited.
Most cited
Ranked by citation count. Because citations accumulate over time, this list naturally leans towards work published a few years ago; for where the field is now, see “recently added”.
The extracellular matrix: A dynamic niche in cancer progression
The Journal of Cell Biology · 2012 · Q1 · SJR 3.00 · FWCI 82.10 · 3,025 citations · Open access
The extracellular matrix (ECM), a key component of the cancer microenvironment, is deregulated in cancer and actively promotes tumor progression and metastasis.
Randomized Trial of Peanut Consumption in Infants at Risk for Peanut Allergy
New England Journal of Medicine · 2015 · Q1 · SJR 18.00 · FWCI 143.81 · 2,217 citations · Open access
Introducing peanuts early to high-risk infants significantly reduced the development of peanut allergy by age 5, with a 1.9% allergy rate in the consumption group versus 13.7% in the avoidance group for those with no initial sensitivity.
EAACI Food Allergy and Anaphylaxis Guidelines: diagnosis and management of food allergy
Allergy · 2014 · Q1 · SJR 3.00 · FWCI 56.94 · 1,364 citations
These evidence-based guidelines from the European Academy of Allergy and Clinical Immunology provide updated recommendations for the diagnosis and management of food allergy.
Targeting integrin pathways: mechanisms and advances in therapy
Signal Transduction and Targeted Therapy · 2023 · Q1 · SJR 17.00 · FWCI 184.96 · 1,215 citations · Open access
Integrins, crucial cell-adhesion receptors, are complex therapeutic targets with only seven drugs successfully marketed despite 40 years of research. However, approximately 90 new integrin-based therapies are currently in clinical studies.
World Allergy Organization Anaphylaxis Guidance 2020
World Allergy Organization Journal · 2020 · Q1 · SJR 1.00 · FWCI 71.32 · 1,109 citations · Open access
The World Allergy Organization (WAO) has updated its 2011 anaphylaxis guidelines, reaffirming intramuscular epinephrine as the first-line treatment while noting its suboptimal use.
Notch signaling pathway: architecture, disease, and therapeutics
Signal Transduction and Targeted Therapy · 2022 · Q1 · SJR 17.00 · FWCI 121.58 · 1,068 citations · Open access
The Notch signaling pathway, identified over a century ago, plays a dual role in cancer, capable of both promoting and inhibiting tumor development, with its targeted therapies thus far failing to meet expectations.
Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology
Allergy · 2014 · Q1 · SJR 3.00 · FWCI 51.79 · 1,053 citations · Open access
New guidelines from the European Academy of Allergy and Clinical Immunology (EAACI) provide evidence-based recommendations for recognizing, assessing risk, and managing anaphylaxis, a potentially life-threatening emergency.
Prevalence and Severity of Food Allergies Among US Adults
JAMA Network Open · 2019 · Q1 · SJR 3.00 · FWCI 65.22 · 1,011 citations
An estimated 10.8% of US adults, over 26 million people, have a confirmed food allergy, with shellfish, milk, and peanut being the most common. Nearly half of these individuals experienced a severe reaction, and almost half are allergic to multiple foods.
ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis
Journal of Leukocyte Biology · 2020 · Q2 · SJR 1.00 · FWCI 47.17 · 966 citations
ICAM-1, a cell surface receptor, is newly recognized not only for its role in leukocyte recruitment during inflammation but also as a master regulator of epithelial injury resolution and immune cell function in tumorigenesis.
RGD-Based Strategies To Target Alpha(v) Beta(3) Integrin in Cancer Therapy and Diagnosis
Molecular Pharmaceutics · 2012 · Q1 · FWCI 26.95 · 943 citations
RGD peptides can selectively bind to the alpha(v)beta(3) integrin, a key molecule in tumor angiogenesis and expressed on tumor cells. This review highlights RGD-based strategies, particularly nanoparticles, for targeted cancer therapy and diagnosis.
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
Molecular Cancer · 2023 · Q1 · SJR 9.00 · FWCI 138.42 · 913 citations · Open access
The extracellular matrix (ECM) actively drives tumor progression and immune evasion by altering its composition, stiffness, and mechanical properties, creating a suppressive microenvironment that hinders cancer treatments.
EAACI Molecular Allergology User's Guide
Pediatric Allergy and Immunology · 2016 · Q1 · SJR 1.00 · FWCI 58.95 · 913 citations · Open access
The EAACI Molecular Allergology User's Guide (MAUG) consolidates current knowledge on allergen molecules and component-resolved diagnosis (CRD) for IgE-mediated allergies.
The skin prick test – European standards
Clinical and Translational Allergy · 2013 · Q1 · SJR 1.00 · FWCI 26.28 · 896 citations · Open access
European standards for skin prick testing are proposed, defining a positive result as a wheal ≥3 mm diameter after 15-20 minutes and recommending a standard panel of 20 common inhalant allergens.
Allergic rhinitis
Nature Reviews Disease Primers · 2020 · Q1 · SJR 15.00 · FWCI 43.79 · 896 citations · Open access
Allergen immunotherapy, when administered by specialists using high-quality extracts in carefully selected patients, proves effective for persistent allergic rhinitis symptoms.
Prevalence of common food allergies in Europe: a systematic review and meta-analysis
Allergy · 2014 · Q1 · SJR 3.00 · FWCI 16.65 · 886 citations
This meta-analysis provides the most up-to-date prevalence estimates for common food allergies in Europe, finding self-reported lifetime prevalence ranging from 0.1% to 6.0% across different allergens.
Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants
New England Journal of Medicine · 2016 · Q1 · SJR 18.00 · FWCI 74.69 · 880 citations · Open access
Early introduction of six allergenic foods (peanut, egg, milk, sesame, fish, wheat) to breast-fed infants did not significantly reduce food allergy rates in an intention-to-treat analysis, but did show benefits in a per-protocol analysis.
The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States
PEDIATRICS · 2018 · Q1 · SJR 2.00 · FWCI 40.99 · 878 citations · Open access
An estimated 7.6% of US children have current food allergies, with peanut, milk, and shellfish being the most common, impacting public health significantly.
TGF-β Activation and Function in Immunity
Annual Review of Immunology · 2013 · Q1 · SJR 16.00 · FWCI 20.09 · 832 citations
Transforming growth factor-beta (TGF-β) is a critical regulator of immune responses, with its activation state determining whether it dampens or promotes T cell activity.
Biology of the Extracellular Matrix
Journal of Glaucoma · 2014 · Q1 · FWCI 2.52 · 797 citations
The extracellular matrix (ECM) is a complex, dynamic network of macromolecules that provides structural integrity to tissues and regulates fundamental cellular behaviors.
EAACI Guidelines on Allergen Immunotherapy: Allergic rhinoconjunctivitis
Allergy · 2017 · Q1 · SJR 3.00 · FWCI 35.36 · 780 citations · Open access
New EAACI guidelines recommend allergen immunotherapy (AIT) for allergic rhinoconjunctivitis (AR) due to its disease-modifying potential, offering a treatment that targets underlying pathophysiology beyond symptom management.
Recently added
Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
Molecular Cancer · 2023 · Q1 · SJR 9.00 · FWCI 138.42 · 913 citations · Open access
The extracellular matrix (ECM) actively drives tumor progression and immune evasion by altering its composition, stiffness, and mechanical properties, creating a suppressive microenvironment that hinders cancer treatments.
The extracellular matrix and the immune system: A mutually dependent relationship
Science · 2023 · Q1 · SJR 10.00 · FWCI 75.93 · 504 citations
The extracellular matrix (ECM), comprising over a third of tissue structures, is an underexplored component in immunology, with its role in determining immune cell localization and function only beginning to be understood.
Targeting integrin pathways: mechanisms and advances in therapy
Signal Transduction and Targeted Therapy · 2023 · Q1 · SJR 17.00 · FWCI 184.96 · 1,215 citations · Open access
Integrins, crucial cell-adhesion receptors, are complex therapeutic targets with only seven drugs successfully marketed despite 40 years of research. However, approximately 90 new integrin-based therapies are currently in clinical studies.
Notch signaling pathway: architecture, disease, and therapeutics
Signal Transduction and Targeted Therapy · 2022 · Q1 · SJR 17.00 · FWCI 121.58 · 1,068 citations · Open access
The Notch signaling pathway, identified over a century ago, plays a dual role in cancer, capable of both promoting and inhibiting tumor development, with its targeted therapies thus far failing to meet expectations.
EAACI guidelines: Anaphylaxis (2021 update)
Allergy · 2021 · Q1 · SJR 3.00 · FWCI 48.98 · 580 citations · Open access
The 2021 EAACI Anaphylaxis guideline recommends using clinical criteria for diagnosis, supported by later tryptase measurement, and prioritizes immediate intramuscular adrenaline as first-line treatment, with readily available autoinjectors for community use.
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