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Neurosurgery· 2026Q1

Awake or Asleep Subthalamic Deep Brain Stimulation for Parkinson's Disease: Further Research Is Needed

Malene Mikkelsen, Katrine Sværke, Sine Fjeldhøj, Rune Rasmussen et al.

Short summary

A systematic review of 2 RCTs and 25 cohort studies found no significant difference in levodopa reduction or quality of life between asleep and awake subthalamic deep brain stimulation (STN-DBS) for Parkinson's disease, though heterogeneity and bias limit conclusions.

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Field: Neurology (Medicine)

NeurologyMedicine