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Nature Genetics· 2026Q1

Type 1 interferon perturbates clonal competition by reshaping human blood development

Chhiring Lama, Danielle Isakov, Shira Rosenberg, Miguel Quijada‐Álamo et al.

Short summary

Interferon-α (IFNα) treatment normalizes blood counts in myeloproliferative neoplasms by promoting lymphoid differentiation and balancing the typical myeloid bias, while also revealing that mutated stem cells resist differentiating into inflammatory myeloid progenitors.

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Field: Genetics

GeneticsMedicine