International Reviews of Immunology· 2026Q1· Review
Immunosenescence and immune–organ axis dysfunction: Potential of algal bioactives and nutritional interventions for healthy ageing
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- Q1SCImago
- 2026year
Short summary
Algal bioactives and nutritional interventions can mitigate aging-related immune system decline and immune-organ axis dysfunction, which contribute to geriatric conditions.
AI-generated from the title and abstract; the full text is not read.
Key points
- Aging-associated immunosenescence impairs immune-organ axis function, worsening geriatric conditions.
- Nutritional interventions, including algal bioactives, can modulate immune pathways via autophagy, inflammation resolution, and cellular repair.
- Stabilization and delivery systems are proposed to enhance the efficacy of these nutritional interventions.
- An integrative approach is needed to address immune dysfunction and improve aging health outcomes.
AI-generated from the title and abstract; the full text is not read.
Abstract
Aging-associated immunosenescence disrupts various immune pathways-signaling, cellular, metabolic, epigenetic, and inflammatory mechanisms-leading to impaired bidirectional interactions between the immune system and organs. This dysfunction exacerbates geriatric conditions, including neurodegenerative disorders, chronic inflammation, and metabolic syndromes. This review introduces the concept of the immune-organ axis, an underexplored framework connecting immune dysregulation to organ-specific dysfunction. Nutritional interventions, including bioactive compounds, essential nutrients, functional foods, and phytochemicals, are highlighted for their ability to modulate these pathways by inducing autophagy, resolving inflammation, and promoting cellular repair. Furthermore, stabilization and delivery systems are proposed as technological solutions to enhance the efficacy of these interventions. This review emphasizes the need for integrative approaches to mitigate immune dysfunction and improve health outcomes in aging populations, while outlining future research directions to advance this field.
The authors' abstract, as published at the source. International Reviews of Immunology, 2026 · DOI ↗
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Field: Aquatic Science
Aquatic ScienceAgricultural and Biological Sciences