Assay and Drug Development Technologies· 2014Q3· Review
Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors
- 2,501citations
- Q3SCImago
- 2014year
Short summary
Three-dimensional (3D) cell cultures offer more physiologically relevant and predictive data for in vivo tests compared to traditional 2D cultures, showing promise for drug discovery and biosensors.
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Key points
- 3D cell cultures provide more physiologically relevant and predictive data than 2D cultures for in vivo applications.
- Key differences between 3D and 2D cultures include cell growth, proliferation, population dynamics, and gene/protein expression.
- Recent advancements in 3D culture systems have improved their utility in drug discovery, especially for evaluating anticancer drug efficacy.
- 3D cell cultures are increasingly applied in the development of cell-based biosensors.
AI-generated from the title and abstract; the full text is not read.
Abstract
Three-dimensional (3D) cell culture systems have gained increasing interest in drug discovery and tissue engineering due to their evident advantages in providing more physiologically relevant information and more predictive data for in vivo tests. In this review, we discuss the characteristics of 3D cell culture systems in comparison to the two-dimensional (2D) monolayer culture, focusing on cell growth conditions, cell proliferation, population, and gene and protein expression profiles. The innovations and development in 3D culture systems for drug discovery over the past 5 years are also reviewed in the article, emphasizing the cellular response to different classes of anticancer drugs, focusing particularly on similarities and differences between 3D and 2D models across the field. The progression and advancement in the application of 3D cell cultures in cell-based biosensors is another focal point of this review.
The authors' abstract, as published at the source. Assay and Drug Development Technologies, 2014 · DOI ↗
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Field: Biomedical Engineering
Biomedical EngineeringEngineering