Bioactive Materials· 2017· Review
Bone grafts and biomaterials substitutes for bone defect repair: A review
- 1,937citations
- 2017year
Short summary
This review highlights that while bone grafts and synthetic substitutes are used for bone defects, their integration with host bone is often compromised, necessitating strategies like incorporating growth factors or bioinorganic ions (Mg, Sr, Zn) to enhance osteointegration.
AI-generated from the title and abstract; the full text is not read.
Key points
- Bone grafts and synthetic substitutes are widely used for bone defect repair but face integration issues.
- Growth factors (BMPs, PTH, PRP) can enhance bone formation but have limitations like high cost and adverse effects.
- Bioinorganic ions (magnesium, strontium, zinc) are emerging as cost-effective alternatives to biological factors for promoting osteointegration.
- The review synthesizes current bone grafts, substitutes, and biological/bio-inorganic factors for bone defect treatment.
AI-generated from the title and abstract; the full text is not read.
Abstract
Bone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft substitutes. Nevertheless, the integration of allogeneic grafts and synthetic substitutes with host bone was found jeopardized in long-term follow-up studies. Hence, the enhancement of osteointegration of these grafts and substitutes with host bone is considerably important. To address this problem, addition of various growth factors, such as bone morphogenetic proteins (BMPs), parathyroid hormone (PTH) and platelet rich plasma (PRP), into structural allografts and synthetic substitutes have been considered. Although clinical applications of these factors have exhibited good bone formation, their further application was limited due to high cost and potential adverse side effects. Alternatively, bioinorganic ions such as magnesium, strontium and zinc are considered as alternative of osteogenic biological factors. Hence, this paper aims to review the currently available bone grafts and bone substitutes as well as the biological and bio-inorganic factors for the treatments of bone defect.
The authors' abstract, as published at the source. Bioactive Materials, 2017 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Biomedical Engineering
Biomedical EngineeringEngineering