PNAS Nexus· 2026Q1
Complementary roles of virtual and real trials in medicine: An interplay of virtuous spirals
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- Q1SCImago
- 2026year
Short summary
Virtual trials offer epistemic opportunities to add mechanistic explainability to the predictive inference of real-world clinical trials.
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Key points
- Virtual trials generate medical knowledge and evidence via computational methods.
- Virtual trials provide epistemic opportunities to add mechanistic explainability to real trials.
- Relating virtual and real trials enables convergence of biological and clinical insights.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Virtual trials provide medical knowledge and practical methods for generating evidence through computational methods. But extending beyond those advantages, they offer epistemic opportunities to add mechanistic explainability to predictive inference of real trials. Relating the distinct contributions and ontology of virtual and real trials enables a transformative convergence of biological and clinical insights that they embody.
The authors' abstract, as published at the source. PNAS Nexus, 2026 · DOI ↗
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Field: History and Philosophy of Science
History and Philosophy of ScienceArts and Humanities