Neurology· 2026Q1
Longitudinal EEG, Seizure, and Developmental Patterns in Children With CDKL5 Deficiency Disorder in the First 2 Years of Life
- 1citations
- Q1SCImago
- 2026year
Short summary
EEGs in children with CDKL5 deficiency disorder (CDD) initially show mild abnormalities that worsen over the first two years of life, correlating with seizure and developmental outcomes.
AI-generated from the title and abstract; the full text is not read.
Key points
- Children with CDD experience progressively worsening EEG abnormalities in the first two years of life.
- Both ictal (seizure) and interictal (between seizures) EEG patterns were analyzed.
- EEG patterns correlate with clinical seizure activity and developmental outcomes.
- The findings provide a longitudinal view of neurological changes in early CDD.
AI-generated from the title and abstract; the full text is not read.
Abstract
Although there is near-universal early-onset epileptic encephalopathy in cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD), it has been observed clinically that EEGs are initially only mildly abnormal and worsen in the first 2 years of life. This study aimed to identify specific EEG patterns, ictal and interictal, in individuals with CDD during the first 2 years of life and to explore their relationship with clinical and developmental outcomes.
The authors' abstract, as published at the source. Neurology, 2026 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Genetics (Biochemistry, Genetics and Molecular Biology)
GeneticsBiochemistry, Genetics and Molecular Biology