Annual Review of Biomedical Engineering· 2012Q1· Review
The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems
- 3,781citations
- Q1SCImago
- 2012year
Short summary
Nanoparticle properties like size, shape, and surface chemistry critically influence their interactions with biological systems, affecting signaling, kinetics, transport, and toxicity.
AI-generated from the title and abstract; the full text is not read.
Key points
- Nanoparticle size, shape, and surface chemistry are key determinants of biological interactions.
- These interactions impact biomolecular signaling, biological kinetics, and transport.
- Toxicity is also a significant factor influenced by nanoparticle properties.
- Research is actively correlating nanomaterial properties with biological responses in vitro and in vivo.
AI-generated from the title and abstract; the full text is not read.
Abstract
An understanding of the interactions between nanoparticles and biological systems is of significant interest. Studies aimed at correlating the properties of nanomaterials such as size, shape, chemical functionality, surface charge, and composition with biomolecular signaling, biological kinetics, transportation, and toxicity in both cell culture and animal experiments are under way. These fundamental studies will provide a foundation for engineering the next generation of nanoscale devices. Here, we provide rationales for these studies, review the current progress in studies of the interactions of nanomaterials with biological systems, and provide a perspective on the long-term implications of these findings.
The authors' abstract, as published at the source. Annual Review of Biomedical Engineering, 2012 · DOI ↗
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Field: Materials Chemistry
Materials ChemistryMaterials Science