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Alzheimer s & Dementia· 2016Q1

Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early‐stage biomarker discovery

Panos Theofilas, Alexander J. Ehrenberg, Sara Dunlop, Ana Tereza Di Lorenzo Alho et al.

Short summary

Locus coeruleus (LC) volume decreases by 8.4% per Braak stage increase in Alzheimer's disease (AD), with neuronal loss only appearing midway through progression.

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Field: Applied Mathematics

Applied MathematicsMathematics