Statistical Methods in Medical Research· 2015Q1
Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable
- 1,955citations
- Q1SCImago
- 2015year
Short summary
A new method recommends pilot trial sample sizes per arm of 75, 25, 15, and 10 for standardized effect sizes of ≤0.1, 0.2, 0.5, and 0.8, respectively, to minimize the total sample size for a continuous outcome in a two-stage trial (pilot + main).
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