Current Stem Cell Research & Therapy· 2014Q2
The Endothelial-Mesenchymal Transition (EndMT) and Tissue Regeneration
- 59citations
- Q2SCImago
- 2014year
Short summary
Endothelial-mesenchymal transition (EndMT)-transformed cells exhibit 'stemness', differentiating into cartilage, bone, and fat cells, suggesting significant potential for tissue engineering and regeneration.
AI-generated from the title and abstract; the full text is not read.
Key points
- EndMT-transformed cells exhibit 'stemness' properties.
- These cells can differentiate into chondroblasts, osteoblasts, and adipoblasts.
- EndMT has potential applications in tissue engineering and regeneration.
- The findings are particularly relevant for cartilage and bone formation.
AI-generated from the title and abstract; the full text is not read.
Abstract
Recent studies have brought endothelial-mesenchymal transition (EndMT) as a special perspective of epithelial- mesenchymal transition (EMT) into eyes. Traditionally, EndMT is considered as a source for fibroblasts and myofibroblasts, and it is extensively investigated in physiologic cardiac development as well as in pathologic tumor and fibrosis. Recently, new studies have found that EndMT-transformed cells had ‘stemness’, which means they could differentiate into chondroblasts, osteoblasts, and adipoblasts in differential culture, respectively. This gives EndMT a bright application future in tissue engineering and regeneration, especially for the formation of cartilage and bone. Keywords: Endothelial-mesenchymal transition (EndMT), endothelial cells, mesenchymal stem cells (MSCs), EndMTtransformed cells, tissue regeneration, transforming growth factor-β (TGF-β).
The authors' abstract, as published at the source. Current Stem Cell Research & Therapy, 2014 · DOI ↗
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Field: Anatomy
AnatomyMedicine