Theranostics· 2024
Standardization and consensus in the development and application of bone organoids
- 55citations
- 2024year
Short summary
A global consortium of experts has established a consensus for standardizing the development, evaluation, and application of bone organoids to improve their accuracy in modeling human bone physiology and pathology.
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Key points
- Bone organoids can replicate complex bone structures and functions, including callus, woven bone, cartilage, trabecular bone, and bone marrow.
- Current bone organoids exhibit significant discrepancies in morphology and functionality compared to human skeletal tissues.
- A consortium of experts has established a consensus to guide standardization in bone organoid construction, evaluation, and application.
- Standardization is crucial for improving the accuracy of bone organoids in modeling human bone physiology and pathology.
AI-generated from the title and abstract; the full text is not read.
Abstract
cellular behavior, tissue architecture, and organ function. Bone organoids, a frontier in organoid research, can replicate the complex structures and functional characteristics of bone tissue. Recent advancements have led to the successful development of bone organoids, including models of callus, woven bone, cartilage, trabecular bone, and bone marrow. These organoids are widely utilized in establishing bone-related disease models, bone injury repair, and drug screening. However, significant discrepancies remain between current bone organoids and human skeletal tissues in terms of morphology and functionality, limiting their ability to accurately model human bone physiology and pathology. To address these challenges and promote standardization in the construction, evaluation, and application of bone organoids, we have convened experts and research teams with substantial expertise in the field. By integrating existing research findings, this consortium aims to establish a consensus to guide future research and application of bone organoids.
The authors' abstract, as published at the source. Theranostics, 2024 · DOI ↗
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Field: Anatomy
AnatomyMedicine