Anesthesiology· 2015Q1· Klinik çalışma
Kronik Sırt ve Bacak Ağrısının Tedavisinde Yeni 10 kHz Yüksek Frekanslı Tedavi (HF10 Tedavisi), Geleneksel Düşük Frekanslı Spinal Kord Stimülasyonundan Üstündür
Novel 10-kHz High-frequency Therapy (HF10 Therapy) Is Superior to Traditional Low-frequency Spinal Cord Stimulation for the Treatment of Chronic Back and Leg Pain
- 832atıf
- Q1SCImago
- 2015yıl
Kısa özet
Yeni bir 10 kHz yüksek frekanslı spinal kord stimülasyonu (HF10 tedavisi), 198 hastanın katıldığı bir denemede, geleneksel düşük frekanslı stimülasyondan önemli ölçüde daha üstün performans göstererek sırt ağrısı için 1.9 kat, bacak ağrısı için ise 1.5 kat daha yüksek yanıt oranı elde etti.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Ana noktalar
- HF10 tedavisi, geleneksel SCS'nin %43.8'ine kıyasla 3. ayda %84.5 sırt ağrısı yanıt oranı elde etti.
- Bacak ağrısı yanıt oranları HF10 için %83.1, geleneksel SCS için %55.5 idi.
- HF10 tedavisinin üstünlüğü 12 aya kadar sürdü.
- HF10 tedavisi, geleneksel SCS'nin yaygın bir yan etkisi olan parestezilere neden olmadı.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Özet (abstract)
AbstractAbstract This randomized trial involving 198 participants demonstrated that high-frequency spinal cord stimulation was superior to conventional spinal cord stimulation for the treatment of back pain and leg pain. The effects of high-frequency stimulation relative to conventional stimulation persisted for 12 months. Background: Current treatments for chronic pain have limited effectiveness and commonly known side effects. Given the prevalence and burden of intractable pain, additional therapeutic approaches are desired. Spinal cord stimulation (SCS) delivered at 10 kHz (as in HF10 therapy) may provide pain relief without the paresthesias typical of traditional low-frequency SCS. The objective of this randomized, parallel-arm, noninferiority study was to compare long-term safety and efficacy of SCS therapies in patients with back and leg pain. Methods: A total of 198 subjects with both back and leg pain were randomized in a 1:1 ratio to a treatment group across 10 comprehensive pain treatment centers. Of these, 171 passed a temporary trial and were implanted with an SCS system. Responders (the primary outcome) were defined as having 50% or greater back pain reduction with no stimulation-related neurological deficit. Results: At 3 months, 84.5% of implanted HF10 therapy subjects were responders for back pain and 83.1% for leg pain, and 43.8% of traditional SCS subjects were responders for back pain and 55.5% for leg pain ( P < 0.001 for both back and leg pain comparisons). The relative ratio for responders was 1.9 (95% CI, 1.4 to 2.5) for back pain and 1.5 (95% CI, 1.2 to 1.9) for leg pain. The superiority of HF10 therapy over traditional SCS for leg and back pain was sustained through 12 months ( P < 0.001). HF10 therapy subjects did not experience paresthesias. Conclusion: HF10 therapy promises to substantially impact the management of back and leg pain with broad applicability to patients, physicians, and payers.
Yazarların özeti; kaynağından alınmıştır. Anesthesiology, 2015 · DOI ↗
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Alan: Anesteziyoloji ve Ağrı Tıbbı
Anesthesiology and Pain MedicineMedicine