Pain· 2016Q1
Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations
- 401citations
- Q1SCImago
- 2016year
Short summary
IMMPACT recommends standardizing patient phenotyping in chronic pain trials to identify subgroups with differential treatment responses, moving towards precision medicine.
AI-generated from the title and abstract; the full text is not read.
Key points
- Patient response to pain treatments varies significantly, hindering clinical practice and trial success.
- Precision medicine aims to tailor treatments based on individual patient characteristics.
- IMMPACT recommends standardizing phenotyping in chronic pain trials.
- Key phenotyping domains include psychosocial factors, symptom characteristics, sleep, pain modulation, and pharmacologic challenge.
- Identifying predictive phenotypic characteristics is crucial for improving treatment efficacy and trial outcomes.
AI-generated from the title and abstract; the full text is not read.
Abstract
There is tremendous interpatient variability in the response to analgesic therapy (even for efficacious treatments), which can be the source of great frustration in clinical practice. This has led to calls for "precision medicine" or personalized pain therapeutics (ie, empirically based algorithms that determine the optimal treatments, or treatment combinations, for individual patients) that would presumably improve both the clinical care of patients with pain and the success rates for putative analgesic drugs in phase 2 and 3 clinical trials. However, before implementing this approach, the characteristics of individual patients or subgroups of patients that increase or decrease the response to a specific treatment need to be identified. The challenge is to identify the measurable phenotypic characteristics of patients that are most predictive of individual variation in analgesic treatment outcomes, and the measurement tools that are best suited to evaluate these characteristics. In this article, we present evidence on the most promising of these phenotypic characteristics for use in future research, including psychosocial factors, symptom characteristics, sleep patterns, responses to noxious stimulation, endogenous pain-modulatory processes, and response to pharmacologic challenge. We provide evidence-based recommendations for core phenotyping domains and recommend measures of each domain.
The authors' abstract, as published at the source. Pain, 2016 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Anesthesiology and Pain Medicine
Anesthesiology and Pain MedicineMedicine