Frontiers in Pharmacology· 2022Q1· Derleme
Diyet Polifenolleri ve Oksidatif Stresin Neden Olduğu İnsan Hastalıklarındaki Rolü: Koruyucu Etkiler, Antioksidan Potansiyeller ve Etki Mekanizmalarına İlişkin Bulgular
Dietary Polyphenols and Their Role in Oxidative Stress-Induced Human Diseases: Insights Into Protective Effects, Antioxidant Potentials and Mechanism(s) of Action
- 1.011atıf
- Q1SCImago
- 2022yıl
Kısa özet
Meyve, sebze ve içeceklerde bulunan diyet polifenolleri, oksidatif strese karşı koruma sağlar ve nörodejeneratif bozukluklar, KKH, kanser ve diyabet gibi kronik hastalıkları önleyebilir.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Ana noktalar
- Diyet polifenolleri meyve, sebze, tahıl ve içecekler gibi çeşitli gıdalarda bulunur.
- Reaktif oksijen türlerini (ROS) ve hücresel oksidatif stresi dengeleyen güçlü antioksidan özelliklere sahiptirler.
- Polifenol açısından zengin diyetlerin uzun süreli tüketimi, kronik hastalıklara karşı koruma ile ilişkilidir.
- Bu hastalıklar arasında nörodejeneratif bozukluklar, kardiyovasküler hastalıklar, kanser, diyabet ve inflamatuar durumlar yer alır.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Özet (abstract)
Dietary polyphenols including phenolic acids, flavonoids, catechins, tannins, lignans, stilbenes, and anthocyanidins are widely found in grains, cereals, pulses, vegetables, spices, fruits, chocolates, and beverages like fruit juices, tea, coffee and wine. In recent years, dietary polyphenols have gained significant interest among researchers due to their potential chemopreventive/protective functions in the maintenance of human health and diseases. It is believed that dietary polyphenols/flavonoids exert powerful antioxidant action for protection against reactive oxygen species (ROS)/cellular oxidative stress (OS) towards the prevention of OS-related pathological conditions or diseases. Pre-clinical and clinical evidence strongly suggest that long term consumption of diets rich in polyphenols offer protection against the development of various chronic diseases such as neurodegenerative diseases, cardiovascular diseases (CVDs), cancer, diabetes, inflammatory disorders and infectious illness. Increased intake of foods containing polyphenols (for example, quercetin, epigallocatechin-3-gallate, resveratrol, cyanidin etc.) has been claimed to reduce the extent of a majority of chronic oxidative cellular damage, DNA damage, tissue inflammations, viral/bacterial infections, and neurodegenerative diseases. It has been suggested that the antioxidant activity of dietary polyphenols plays a pivotal role in the prevention of OS-induced human diseases. In this narrative review, the biological/pharmacological significance of dietary polyphenols in the prevention of and/or protection against OS-induced major human diseases such as cancers, neurodegenerative diseases, CVDs, diabetes mellitus, cancer, inflammatory disorders and infectious diseases have been delineated. This review specifically focuses a current understanding on the dietary sources of polyphenols and their protective effects including mechanisms of action against various major human diseases.
Yazarların özeti; kaynağından alınmıştır. Frontiers in Pharmacology, 2022 · DOI ↗
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