AYU (An International Quarterly Journal of Research in Ayurveda)· 2012
Drug discovery from plant sources: An integrated approach
- 490citations
- 2012year
Short summary
An integrated drug discovery approach combining Ayurvedic wisdom with plant-based isolation methods can reduce costs, save time, and increase success rates compared to traditional methods.
AI-generated from the title and abstract; the full text is not read.
Key points
- New drug discovery faces challenges with declining approvals and rising costs, despite advancements like combinatorial chemistry.
- An integrated approach combines Ayurvedic wisdom with plant-based isolation for drug discovery.
- Candidate plants are identified using Ayurvedic principles, traditional use, and literature searches.
- Bioactivity-guided fractionation of selected plants yields standardized extracts or bioactive compounds.
- This integrated method promises cost and time savings with an enhanced success rate.
AI-generated from the title and abstract; the full text is not read.
Abstract
New drug discovery is facing serious challenges due to reduction in number of new drug approvals coupled with exorbitant rising cost. Advent of combinatorial chemistry provided new hope of higher success rates of new chemical entities (NCEs); however, even this scientific development has failed to improve the success rate in new drug discovery. This scenario has prompted us to come out with a novel approach of integrated drug discovery, where Ayurvedic wisdom can synergize with drug discovery from plant sources. Initial steps in new drug discovery involve identification of NCEs, which can be either sourced through chemical synthesis or can be isolated from natural products through biological activity guided fractionation. The sources of many of the new drugs and active ingredients of medicines are derived from natural products. The starting point for plant-based new drug discovery should be identification of the right candidate plants by applying Ayurvedic wisdom, traditional documented use, tribal non-documented use, and exhaustive literature search. Frequency analysis of the ingredients of the ancient documented formulations and analysis of their Ayurvedic attributes may provide an in-depth idea of the predominance of particular Ayurvedic characteristics based on which appropriate candidate plants may be selected for bioactivity-based fractionation. The integration of Ayurvedic wisdom with drug discovery also brings the need for a paradigm shift in the extraction process from sequential to parallel extraction. Bioassay-guided fractionation of the identified plant may lead to standardized extract or isolated bioactive druggable compound as the new drug. This integrated approach would lead to saving of cost and time, coupled with enhanced success rate in drug discovery.
The authors' abstract, as published at the source. AYU (An International Quarterly Journal of Research in Ayurveda), 2012 · DOI ↗
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Field: Complementary and alternative medicine
Complementary and alternative medicineMedicine