Science· 2022Q1
Microbiota and maintenance of skin barrier function
- 627citations
- Q1SCImago
- 2022year
Short summary
The skin microbiota actively fortifies the epithelial barrier, protects against pathogens, and tunes immune responses, playing a crucial role in maintaining skin health.
AI-generated from the title and abstract; the full text is not read.
Key points
- The skin microbiota is essential for barrier function, pathogen defense, and immune modulation.
- Host-microbiota interactions are implicated in various skin disorders.
- Targeting microbiota mechanisms can be used to treat skin conditions and enhance wound healing.
AI-generated from the title and abstract; the full text is not read.
Abstract
Human skin forms a protective barrier against the external environment and is our first line of defense against toxic, solar, and pathogenic insults. Our skin also defines our outward appearance, protects our internal tissues and organs, acts as a sensory interface, and prevents dehydration. Crucial to the skin's barrier function is the colonizing microbiota, which provides protection against pathogens, tunes immune responses, and fortifies the epithelium. Here we highlight recent advances in our understanding of how the microbiota mediates multiple facets of skin barrier function. We discuss recent insights into pathological host-microbiota interactions and implications for disorders of the skin and distant organs. Finally, we examine how microbiota-based mechanisms can be targeted to prevent or manage skin disorders and impaired wound healing.
The authors' abstract, as published at the source. Science, 2022 · DOI ↗
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Field: Dermatology
DermatologyMedicine