Allergy and Asthma Proceedings· 2019Q2
Pathophysiology of atopic dermatitis: Clinical implications
- 625citations
- Q2SCImago
- 2019year
Short summary
Atopic dermatitis (AD) involves genetic predisposition, epidermal barrier disruption, and immune system dysregulation, with Type 2 cytokines, IL-17, and IL-22 contributing to skin barrier dysfunction and inflammation.
AI-generated from the title and abstract; the full text is not read.
Key points
- AD pathogenesis involves genetic factors, epidermal barrier defects, and immune system imbalance.
- Skin barrier impairment can be an initial step in AD development and allergic sensitization.
- Type 2 cytokines, IL-17, and IL-22 play roles in AD by affecting skin barrier function.
- Current research focuses on lipid profiles, neuroimmune interactions, and microbial dysbiosis.
- Therapeutic strategies aim to enhance skin barrier function and target specific immune pathways.
AI-generated from the title and abstract; the full text is not read.
Abstract
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. Genetic predisposition, epidermal barrier disruption, and dysregulation of the immune system are some of the critical components of AD. An impaired skin barrier may be the initial step in the development of the atopic march as well as AD, which leads to further skin inflammation and allergic sensitization. Type 2 cytokines as well as interleukin 17 and interleukin 22 contribute to skin barrier dysfunction and the development of AD. New insights into the pathophysiology of AD have focused on epidermal lipid profiles, neuroimmune interactions, and microbial dysbiosis. Newer therapeutic strategies focus on improving skin barrier function and targeting polarized immune pathways found in AD. Further understanding of AD pathophysiology will allow us to achieve a more precision medicine approach to the prevention and the treatment of AD.
The authors' abstract, as published at the source. Allergy and Asthma Proceedings, 2019 · DOI ↗
Continue with a free account
Ask the paper: 3 free questions a day about this paper; save it, get its citation, new summaries every day for your field. Takeaways are Premium.
Continue free on the webSign in with Google or Apple; no card needed. You come back to this paper.
On your phone:
Field: Dermatology
DermatologyMedicine