Nature Communications· 2026Q1
Genome-wide cross-trait analysis to compare genetic architecture between Parkinson’s disease and kidney-related traits
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- 2026year
Short summary
Genome-wide analysis of Parkinson's disease (PD) and five kidney traits identified shared genetic loci, with four loci implicating BIN3, MSRA, and TNK2 in protein quality control, suggesting a shared genetic basis for the kidney-brain axis in neurodegeneration.
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Key points
- Genome-wide analysis combined genetic correlation, pleiotropy mapping, colocalization, and enrichment for PD and five kidney traits.
- Modest genetic correlation was observed between PD and kidney traits, with only urinary potassium-to-creatinine ratio showing significance.
- Shared genetic loci were identified across 9 of 15 trait pairs, though often driven by different causal variants.
- Four loci, implicating BIN3, MSRA, and TNK2, were driven by a shared causal variant and linked to protein quality control.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract Epidemiological studies link kidney function to Parkinson’s disease risk, but the genetic basis of this relationship remains unclear. Here, we leverage genome-wide association data for Parkinson’s disease and five UK Biobank-derived kidney-related traits in individuals of European ancestry, combining genetic correlation, pleiotropy mapping, colocalization and enrichment across sex-combined and sex-stratified analyses. Genome-wide genetic correlations with Parkinson’s are modest, with only a significant correlation with urinary potassium-to-creatinine ratio significant, yet we identify shared loci across 9 of 15 trait pairs. Resolving these loci, the two traits are more often driven by different causal variants within a shared region than by the same variant. Four loci carry a shared causal variant, implicating BIN3 , MSRA and TNK2 in protein quality control. These findings provide evidence for shared genomic loci between Parkinson’s disease and kidney function, offering specific loci and biological pathways for future investigation of the kidney-brain axis in neurodegeneration.
The authors' abstract, as published at the source. Nature Communications, 2026 · DOI ↗
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Field: Genetics (Biochemistry, Genetics and Molecular Biology)
GeneticsBiochemistry, Genetics and Molecular Biology