Cellular Physiology and Biochemistry· 2015Q3
Antihyperlipidemic and Biochemical Activities of Mcy Protein in Streptozotocin Induced Diabetic Rats
- 5,950citations
- Q3SCImago
- 2015year
Short summary
A novel Mcy protein from Momordica cymbalaria significantly reduced fasting blood glucose and serum/tissue lipid levels in diabetic rats, while also normalizing liver and kidney function markers.
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Key points
- Mcy protein significantly reduced fasting blood glucose (p<0.05) in diabetic rats.
- Mcy protein lowered serum and tissue lipid levels in treated diabetic rats.
- Liver and kidney function markers were normalized by Mcy protein treatment.
- Pancreatic islet regeneration was observed in Mcy protein-treated rats.
AI-generated from the title and abstract; the full text is not read.
Abstract
BACKGROUND: This study was aimed to evaluate the protective effects of a novel anti-hyperglycemic "Mcy protein" isolated from the fruits of Momordica cymbalaria in streptozotocin induced- diabetes rat model. MATERIALS AND METHODS: Wild type and Streptozotocin induced diabetic male wistar albino rats were either treated with single intraperitoneal injection of 2.5 mg Mcy protein/kg body weight or acetate buffer daily for 30 days. Fasting blood glucose and, serum and tissue lipid levels were measured along with biochemical analysis for hepatic and renal function tests. RESULTS: Mcy protein significantly reduced the fasting blood glucose and, serum as well as tissue lipid levels (p<0.05), besides normalizing the levels of liver and kidney function markers in the treated diabetic rats when compared to the diabetic controls. Our studies also showed the pancreatic islet regeneration in Mcy treated rats. CONCLUSION: Mcy protein can alleviate hyperlipidemia and help manage diabetes by stimulating insulin secretion without evident toxic effects on liver and kidney.
The authors' abstract, as published at the source. Cellular Physiology and Biochemistry, 2015 · DOI ↗
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Field: Endocrinology, Diabetes and Metabolism
Endocrinology, Diabetes and MetabolismMedicine