iScience· 2026Q1
Hippo sinyali Drosophila kafası ve göz gelişiminde dorsoventral desenlenmeyi düzenler
Hippo signaling regulates dorsoventral patterning in Drosophila head and eye development
- 0atıf
- Q1SCImago
- 2026yıl
Kısa özet
Drosophila'da, Hippo yolu efektörü Yorkie (Yki) dorsal kafa boyutunu ve desenlenmesini desteklerken, Defective Proventriculus (Dve) transkripsiyon faktörü bu bölgede Yki'yi baskılayarak göz ve kafa gelişimini koordine eder.
Yapay zekâ ile başlık ve abstract'tan üretildi; tam metin okunmaz.
Özet (abstract)
The integration of growth and patterning is essential for proper tissue development. In Drosophila , the Hippo pathway controls organ size, including formation of adult structures from the eye-antennal imaginal disc. Defective Proventriculus (Dve), a K-50 domain transcription factor, regulates dorsal-ventral patterning by suppressing eye fate and promoting head cuticle development, thereby influencing eye position and interocular distance. We investigated how the Hippo effector Yorkie (Yki) and Dve coordinate growth and patterning in the dorsal head region. Our results show that Yki regulates dorsal head size, while Dve suppresses Yki in this region. Yki also controls dorsal-ventral patterning genes, including pnr, wg , and mirr , to coordinate eye and head development. Because mammalian orthologs of yki, dve, pnr , and wg are linked to developmental disorders such as facial dysmorphia, our findings reveal conserved mechanisms connecting growth, patterning, and craniofacial development across species, with potential relevance to human developmental disease and tissue morphogenesis.
Yazarların özeti; kaynağından alınmıştır. iScience, 2026 · DOI ↗
Devamı Pofolia uygulamasında
Çıkarımlar, ana noktalar ve makaleye soru sorma; ilgi alanına göre her gün yeni özetler. Ücretsiz.
Web'de giriş yaparak açCell BiologyBiochemistry, Genetics and Molecular Biology