Journal of Natural Products· 2026Q1
(±)-Nigronetides A−D and Nigronetides E−H, Complex Polyketides Produced by the Marine-Derived Fungus Nigrograna sp. M13
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- Q1SCImago
- 2026year
Short summary
Eight complex polyketides, including three novel carbon skeletons, were isolated from the marine fungus Nigrograna sp. M13.
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Key points
- Eight polyketides, (±)-nigronetides A−D (1−4) and E−H (5−8), were isolated from Nigrograna sp. M13.
- Three novel carbon skeletons were identified among the isolated compounds.
- Structural elucidation involved spectroscopic data, NOESY, quantum chemical NMR, and ECD calculations.
- Compounds A-D were isolated as scalemic mixtures.
- None of the compounds exhibited antiplasmodial or cytotoxic activity.
AI-generated from the title and abstract; the full text is not read.
Abstract
Abstract (±)-Nigronetides A−D (1−4) and nigronetides E−H (5−8), polyketides with complex carbon skeletons, were isolated from cultures of the marine-derived fungus Nigrograna sp. M13, presenting three novel carbon skeletons. While the planar structures and relative configuration of (±)-nigronetides A−D (1−4) were established by analysis of spectroscopic data, the absolute configuration of nigronetides E−H (5−8) was assigned using a combination of analysis of NOESY data, quantum chemical NMR calculations, as well as by comparison between experimental and calculated electronic circular dichroism (ECD) spectra. (±)-Nigronetides A−D (1−4) were isolated as scalemic mixtures of an almost identical ratio between enantiomers. Compounds 1−8 were inactive in antiplasmodial assays against the Plasmodium falciparum 3D7 strain as well as in cytotoxicity assays against several cancer cell lines.
The authors' abstract, as published at the source. Journal of Natural Products, 2026 · DOI ↗
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Field: Pharmacology (Medicine)
PharmacologyMedicine