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New England Journal of Medicine· 2015Q1

Glioma Groups Based on 1p/19q,<i>IDH</i>, and<i>TERT</i>Promoter Mutations in Tumors

Jeanette E. Eckel‐Passow, Daniel H. Lachance, Annette M Molinaro, Kyle M. Walsh et al.

Short summary

Gliomas can be classified into five distinct molecular groups based on three key genetic alterations: TERT promoter mutations, IDH mutations, and 1p/19q codeletion. These groups exhibit significant differences in age at diagnosis, overall survival, and associations with inherited genetic predispositions.

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Field: Genetics

GeneticsMedicine