Clinical journal of oncology nursing· 2016Q3· Review
Glioblastoma: Overview of Disease and Treatment
- 1,216citations
- Q3SCImago
- 2016year
Short summary
New therapies like tumor-treating fields (TTFields) and immunotherapy offer hope for improved survival in glioblastoma (GBM), the most aggressive adult brain tumor, despite multimodal treatments like surgery, radiation, and chemotherapy.
AI-generated from the title and abstract; the full text is not read.
Key points
- Glioblastoma (GBM) is the most common and aggressive adult malignant brain tumor.
- Current standard treatments include surgical resection, radiation, and chemotherapy.
- Despite aggressive treatment, GBM frequently recurs.
- New therapies like tumor-treating fields (TTFields) and immunotherapy are showing promise for improved survival.
AI-generated from the title and abstract; the full text is not read.
Abstract
BACKGROUND: Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults. Current treatment options at diagnosis are multimodal and include surgical resection, radiation, and chemotherapy. Significant advances in the understanding of the molecular pathology of GBM and associated cell signaling pathways have opened opportunities for new therapies for recurrent and newly diagnosed disease. Innovative treatments, such as tumor-treating fields (TTFields) and immunotherapy, give hope for enhanced survival. OBJECTIVES: This article reviews the background, risks, common complications, and treatment options for GBM. METHODS: A brief review of GBM, treatment options, and a look at new therapies that have been approved for new and recurrent disease are included in this article. FINDINGS: Despite aggressive resection and combined modality adjuvant treatment, most GBMs recur. Treatments, such as TTFields, drugs to target molecular receptors, and immunotherapy, are promising new options.
The authors' abstract, as published at the source. Clinical journal of oncology nursing, 2016 · DOI ↗
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Field: Genetics (Medicine)
GeneticsMedicine