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New England Journal of Medicine· 2017Q1

Short-Course Radiation plus Temozolomide in Elderly Patients with Glioblastoma

James Perry, Normand Laperrière, Christopher J. O’Callaghan, Alba A. Brandes et al.

Short summary

Adding temozolomide chemotherapy to short-course radiotherapy (40 Gy in 15 fractions) significantly increased median overall survival by 5.8 months (13.5 vs. 7.7 months) in elderly patients (≥65 years) with glioblastoma, particularly those with methylated MGMT status.

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Field: Genetics

GeneticsMedicine