Cell Death and Disease· 2016Q1· Review
Mesenchymal stem cells and immunomodulation: current status and future prospects
- 1,159citations
- Q1SCImago
- 2016year
Short summary
Mesenchymal stem cells (MSCs) show promise for treating inflammatory and autoimmune disorders due to their unique immunomodulatory properties, but widespread clinical application faces challenges.
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Key points
- MSCs have unique immunomodulatory properties beneficial for repairing tissue damage from inflammation and autoimmune disorders.
- MSCs show promise for treating conditions like GvHD and allergic disorders.
- Widespread clinical application of MSCs faces significant challenges.
- Understanding MSC biological properties is key to clarifying their immunomodulatory mechanisms.
- Pluripotent stem cell-derived MSCs are proposed as a future approach for immunomodulation therapy.
AI-generated from the title and abstract; the full text is not read.
Abstract
The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them an invaluable cell type for the repair of tissue/ organ damage caused by chronic inflammation or autoimmune disorders. Although they hold great promise in the treatment of immune disorders such as graft versus host disease (GvHD) and allergic disorders, there remain many challenges to overcome before their widespread clinical application. An understanding of the biological properties of MSCs will clarify the mechanisms of MSC-based transplantation for immunomodulation. In this review, we summarize the preclinical and clinical studies of MSCs from different adult tissues, discuss the current hurdles to their use and propose the future development of pluripotent stem cell-derived MSCs as an approach to immunomodulation therapy.
The authors' abstract, as published at the source. Cell Death and Disease, 2016 · DOI ↗
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Field: Genetics (Medicine)
GeneticsMedicine