Science· 2013Q1

Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells

Jan Krönke, Namrata D. Udeshi, Anupama Narla, Peter Grauman et al.

1,851citations
Q1SCImago
2013year

Short summary

Lenalidomide selectively targets and degrades lymphoid transcription factors IKZF1 and IKZF3 in multiple myeloma cells via the CRBN-CRL4 ubiquitin ligase.

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Field: Hematology

HematologyMedicine